A Single-Chain-Based Hexavalent CD27 Agonist Enhances T Cell Activation and Induces Anti-Tumor Immunity

A Single-Chain-Based Hexavalent CD27 Agonist Enhances T Cell Activation and Induces Anti-Tumor Immunity

Tumor necrosis factor receptor superfamily member 7 (TNFRSF7, CD27), expressed primarily by T cells, and its ligand CD27L (TNFSF7, CD70) provide co-stimulatory signals that boost T cell activation, differentiation, and survival. Agonistic stimulation of CD27 is therefore a promising therapeutic conc...

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Bibliographic Details
Main Authors: Meinolf Thiemann, David M. Richards, Karl Heinonen, Michael Kluge, Viola Marschall, Christian Merz, Mauricio Redondo Müller, Tim Schnyder, Julian P. Sefrin, Jaromir Sykora, Harald Fricke, Christian Gieffers, Oliver Hill
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Oncology
Subjects:
single-chain CD27L
scCD27L-RBD
CD27
agonist
TNFSF
TNFRSF7
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00387/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2018.00387/full

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