Hypoxia-autophagy axis induces VEGFA by peritoneal mesothelial cells to promote gastric cancer peritoneal metastasis through an integrin α5-fibronectin pathway

Hypoxia-autophagy axis induces VEGFA by peritoneal mesothelial cells to promote gastric cancer peritoneal metastasis through an integrin α5-fibronectin pathway

Abstract Background Peritoneal metastasis (PM) is an important pathological process in the progression of gastric cancer (GC). The metastatic potential of tumor and stromal cells is governed by hypoxia, which is a key molecular feature of the tumor microenvironment. Mesothelial cells also participat...

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Bibliographic Details
Main Authors: Xiaoxun Wang, Xiaofang Che, Yang Yu, Yu Cheng, Ming Bai, Zichang Yang, Qiqiang Guo, Xiaochen Xie, Danni Li, Min Guo, Kezuo Hou, Wendong Guo, Xiujuan Qu, Liu Cao
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Hypoxia
Autophagy
VEGFA
Migration
Adhesion
Online Access:http://link.springer.com/article/10.1186/s13046-020-01703-x

Internet

http://link.springer.com/article/10.1186/s13046-020-01703-x

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