A Mutational Analysis of Residues in Cholera Toxin A1 Necessary for Interaction with Its Substrate, the Stimulatory G Protein Gsα

A Mutational Analysis of Residues in Cholera Toxin A1 Necessary for Interaction with Its Substrate, the Stimulatory G Protein Gsα

Pathogenesis of cholera diarrhea requires cholera toxin (CT)-mediated adenosine diphosphate (ADP)-ribosylation of stimulatory G protein (Gsα) in enterocytes. CT is an AB5 toxin with an inactive CTA1 domain linked via CTA2 to a pentameric receptor-binding B subunit. Allosterically activated CTA1 frag...

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Bibliographic Details
Main Authors: Michael G. Jobling, Lisa F. Gotow, Zhijie Yang, Randall K. Holmes
Format: Article
Language:English
Published: MDPI AG 2015-03-01
Series:Toxins
Subjects:
cholera toxin
Gs alpha
ADP-ribosylation
Online Access:http://www.mdpi.com/2072-6651/7/3/919

Internet

http://www.mdpi.com/2072-6651/7/3/919

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