Intercellular transfer of mitochondrial DNA carrying metastasis-enhancing pathogenic mutations from high- to low-metastatic tumor cells and stromal cells via extracellular vesicles

Intercellular transfer of mitochondrial DNA carrying metastasis-enhancing pathogenic mutations from high- to low-metastatic tumor cells and stromal cells via extracellular vesicles

Abstract Background Mitochondrial DNA (mtDNA) carrying certain pathogenic mutations or single nucleotide variants (SNVs) enhances the invasion and metastasis of tumor cells, and some of these mutations are homoplasmic in tumor cells and even in tumor tissues. On the other hand, intercellular transfe...

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Bibliographic Details
Main Authors: Keizo Takenaga, Nobuko Koshikawa, Hiroki Nagase
Format: Article
Language:English
Published: BMC 2021-10-01
Series:BMC Molecular and Cell Biology
Subjects:
Mitochondria
Mitochondrial DNA
Mutation
Extracellular vesicles
Intercellular transfer
Lung cancer
Online Access:https://doi.org/10.1186/s12860-021-00391-5

Internet

https://doi.org/10.1186/s12860-021-00391-5

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