Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication

Summary: The protein deacetylase SIRT1 (Sirtuin 1) regulates many cellular processes, including cell-cycle progression, DNA damage response, and metabolism. Although the centrosome is a key regulator of cell-cycle progression and genome stability, little is known concerning SIRT1 controlled centroso...

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Bibliographic Details
Main Authors: Hongbo Ling, Lirong Peng, Jianbo Wang, Raneen Rahhal, Edward Seto
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718317716