Alternative Splicing of CHEK2 and Codeletion with NF2 Promote Chromosomal Instability in Meningioma

Alternative Splicing of CHEK2 and Codeletion with NF2 Promote Chromosomal Instability in Meningioma

Mutations of the NF2 gene on chromosome 22q are thought to initiate tumorigenesis in nearly 50% of meningiomas, and 22q deletion is the earliest and most frequent large-scale chromosomal abnormality observed in these tumors. In aggressive meningiomas, 22q deletions are generally accompanied by the...

Full description

Bibliographic Details
Main Authors: Hong Wei Yang, Tae-Min Kim, Sydney S. Song, Nihal Shrinath, Richard Park, Michel Kalamarides, Peter J. Park, Peter M. Black, Rona S. Carroll, Mark D. Johnson
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558612800741

Internet

http://www.sciencedirect.com/science/article/pii/S1476558612800741

Similar Items