Mechanistic insights into validoxylamine A 7'-phosphate synthesis by VldE using the structure of the entire product complex.

Mechanistic insights into validoxylamine A 7'-phosphate synthesis by VldE using the structure of the entire product complex.

The pseudo-glycosyltransferase VldE catalyzes non-glycosidic C-N coupling between an unsaturated cyclitol and a saturated aminocyclitol with the conservation of the stereochemical configuration of the substrates to form validoxylamine A 7'-phosphate, the biosynthetic precursor of the antibiotic...

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Bibliographic Details
Main Authors: Michael C Cavalier, Young-Sun Yim, Shumpei Asamizu, David Neau, Khaled H Almabruk, Taifo Mahmud, Yong-Hwan Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3441724?pdf=render

Internet

http://europepmc.org/articles/PMC3441724?pdf=render

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