Mammalian target of rapamycin inhibition in polycystic kidney disease: From bench to bedside

Autosomal dominant polycystic kidney disease (ADPKD) is the most common life-threatening hereditary disease in the USA resulting in chronic kidney disease and the need for dialysis and transplantation. Approximately 85% of cases of ADPKD are caused by a mutation in the Pkd1 gene that encodes polycys...

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Bibliographic Details
Main Authors: Hyun-Jung Kim, Charles L. Edelstein
Format: Article
Language:English
Published: The Korean Society of Nephrology 2012-09-01
Series:Kidney Research and Clinical Practice
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211913212007115