Epidermal growth factor-mediated Rab25 pathway regulates integrin β1 trafficking in colon cancer

Epidermal growth factor-mediated Rab25 pathway regulates integrin β1 trafficking in colon cancer

Abstract Background Integrins play a critical role in carcinogenesis. Integrin β1 localization is regulated by the guanosine-5′-triphosphate hydrolase Rab25 and integrin β1 levels are elevated in the serum of colon cancer patients; thus, the present study examined the effects of epidermal growth fac...

Full description

Bibliographic Details
Main Authors: Kyung Sook Hong, Eun-Young Jeon, Soon Sup Chung, Kwang Ho Kim, Ryung-Ah Lee
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Cancer Cell International
Subjects:
Colonic neoplasms
Receptor trafficking
Endocytosis
Shedding
Integrins
Epidermal growth factor
Online Access:http://link.springer.com/article/10.1186/s12935-018-0526-y

Internet

http://link.springer.com/article/10.1186/s12935-018-0526-y

Similar Items