Transcriptome Profiling of Human Monocyte-Derived Macrophages Upon CCL2 Neutralization Reveals an Association Between Activation of Innate Immune Pathways and Restriction of HIV-1 Gene Expression

Transcriptome Profiling of Human Monocyte-Derived Macrophages Upon CCL2 Neutralization Reveals an Association Between Activation of Innate Immune Pathways and Restriction of HIV-1 Gene Expression

Macrophages are key targets of human immunodeficiency virus type 1 (HIV-1) infection and main producers of the proinflammatory chemokine CC chemokine ligand 2 (CCL2), whose expression is induced by HIV-1 both in vitro and in vivo. We previously found that CCL2 neutralization in monocyte-derived macr...

Full description

Bibliographic Details
Main Authors: Daniela Angela Covino, Karolina Elżbieta Kaczor-Urbanowicz, Jing Lu, Maria Vincenza Chiantore, Gianna Fiorucci, Maria Fenicia Vescio, Laura Catapano, Cristina Purificato, Clementina Maria Galluzzo, Roberta Amici, Mauro Andreotti, Maria Cristina Gauzzi, Matteo Pellegrini, Laura Fantuzzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
HIV-1
macrophage
CCL2 (MCP-1)
innate response
RNA-sequencing
transcriptional profile
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.02129/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.02129/full

Similar Items