Heparan Sulfate Structure Affects Autophagy, Lifespan, Responses to Oxidative Stress, and Cell Degeneration in Drosophila parkin Mutants

Heparan Sulfate Structure Affects Autophagy, Lifespan, Responses to Oxidative Stress, and Cell Degeneration in Drosophila parkin Mutants

Autophagy is a catabolic process that provides cells with energy and molecular building blocks during nutritional stress. Autophagy also removes misfolded proteins and damaged organelles, a critical mechanism for cellular repair. Earlier work demonstrated that heparan sulfate proteoglycans, an abund...

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Bibliographic Details
Main Authors: Claire Reynolds-Peterson, Jie Xu, Na Zhao, Casey Cruse, Brandon Yonel, Claire Trasorras, Hidenao Toyoda, Akiko Kinoshita-Toyoda, Jennifer Dobson, Nicholas Schultheis, Mei Jiang, Scott Selleck
Format: Article
Language:English
Published: Oxford University Press 2020-01-01
Series:G3: Genes, Genomes, Genetics
Subjects:
heparan sulfate modified proteins
autophagy
mitophagy
parkin
presenilin
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.119.400730

Internet

http://g3journal.org/lookup/doi/10.1534/g3.119.400730

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