N-methyl-D-aspartate receptor availability in first-episode psychosis: a PET-MR brain imaging study

Abstract N-methyl-D-aspartate receptor (NMDAR) hypofunction is hypothesised to underlie psychosis but this has not been tested early in illness. To address this, we studied 40 volunteers (21 patients with first-episode psychosis and 19 matched healthy controls) using PET imaging with an NMDAR select...

Full description

Bibliographic Details
Main Authors: Katherine Beck, Atheeshaan Arumuham, Mattia Veronese, Barbara Santangelo, Colm J. McGinnity, Joel Dunn, Robert A. McCutcheon, Stephen J. Kaar, Nisha Singh, Toby Pillinger, Faith Borgan, James Stone, Sameer Jauhar, Teresa Sementa, Federico Turkheimer, Alexander Hammers, Oliver D. Howes
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-021-01540-2