In vivo amyloid-β imaging in the APPPS1-21 transgenic mouse model with a 89Zr- labeled monoclonal antibody.

In vivo amyloid-β imaging in the APPPS1-21 transgenic mouse model with a 89Zr- labeled monoclonal antibody.

Introduction: The accumulation of amyloid-β is a pathological hallmark of Alzheimer’s disease and is a target for molecular imaging probes to aid in diagnosis and disease monitoring. This study evaluated the feasibility of using a radiolabeled monoclonal anti-amyloid-β antibody (JRF/AβN/25) to non-i...

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Bibliographic Details
Main Authors: Ann-Marie eWaldron, Jens eFissers, Annemie evan Eetveldt, Bianca eVan Broeck, Mark eMercken, Darrel J Pemberton, Pieter eVan der Veken, Koen eAugustyns, Jurgen eJoossens, Sigrid eStroobants, Stefanie eDedeurwaerdere, Leonie ewyffels, Steven eStaelens
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
Monoclonal antibody
Small animal imaging
Amyloid imaging
Alzheimer.
89Zirconium
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00067/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00067/full

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