Inhibition of Hepatitis C Virus in Mice by a Small Interfering RNA Targeting a Highly Conserved Sequence in Viral IRES Pseudoknot.

Inhibition of Hepatitis C Virus in Mice by a Small Interfering RNA Targeting a Highly Conserved Sequence in Viral IRES Pseudoknot.

The hepatitis C virus (HCV) internal ribosome entry site (IRES) that directs cap-independent viral translation is a primary target for small interfering RNA (siRNA)-based HCV antiviral therapy. However, identification of potent siRNAs against HCV IRES by bioinformatics-based siRNA design is a challe...

Full description

Bibliographic Details
Main Authors: Jae-Su Moon, Seung-Hoon Lee, Eun-Jung Kim, Hee Cho, Wooseong Lee, Geon-Woo Kim, Hyun-Ji Park, Seung-Woo Cho, Choongho Lee, Jong-Won Oh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4713436?pdf=render

Internet

http://europepmc.org/articles/PMC4713436?pdf=render

Similar Items