Association of PTPRD/PTPRT Mutation With Better Clinical Outcomes in NSCLC Patients Treated With Immune Checkpoint Blockades

Association of PTPRD/PTPRT Mutation With Better Clinical Outcomes in NSCLC Patients Treated With Immune Checkpoint Blockades

The common gamma receptor–dependent cytokines and their JAK-STAT pathways play important roles in T cell immunity and have been demonstrated to be related with response to immune checkpoint blockades (ICBs). PTPRD and PTPRT are phosphatases involved in JAK-STAT pathway. However, their clinical signi...

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Bibliographic Details
Main Authors: Xiaoyan Wang, Bingchen Wu, Zhengqing Yan, Guoqiang Wang, Shiqing Chen, Jian Zeng, Feng Tao, Bichun Xu, Honggang Ke, Mei Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
PTPRD
PTPRT
JAK-STAT
immune checkpoint blockades
non-small cell lung cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.650122/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.650122/full

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