Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets
The source of phospholipids to generate autophagosomal membranes, particularly after prolonged starvation, is not well characterized. Here, the authors show that CCTβ3, the rate limiting enzyme in phosphatidylcholine synthesis, is activated on lipid droplets and sustains long-term autophagy.
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2020-09-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18153-w |