The Curcumin Derivative, H10, Suppresses Hormone-Dependent Prostate Cancer by Inhibiting 17β-Hydroxysteroid Dehydrogenase Type 3

The Curcumin Derivative, H10, Suppresses Hormone-Dependent Prostate Cancer by Inhibiting 17β-Hydroxysteroid Dehydrogenase Type 3

The 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) enzyme is a potential therapeutic target for hormone-dependent prostate cancer, as it is the key enzyme in the last step of testosterone (T) biosynthesis. A curcumin analog, H10, was optimized for inhibiting T production in LC540 cells that stab...

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Bibliographic Details
Main Authors: Yating Cheng, Yan Yang, Yinan Wu, Wencheng Wang, Lichun Xiao, Yifan Zhang, Jianzhong Tang, Ya-Dong Huang, Shu Zhang, Qi Xiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
curcumin derivatives
17β-hydroxysteroid dehydrogenase type 3
inhibitor
prostate cancer
hormone-dependent
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00637/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00637/full

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