β-TrCP Restricts Lipopolysaccharide (LPS)-Induced Activation of TRAF6-IKK Pathway Upstream of IκBα Signaling

β-TrCP Restricts Lipopolysaccharide (LPS)-Induced Activation of TRAF6-IKK Pathway Upstream of IκBα Signaling

β transducin repeat-containing protein (β-TrCP) is a Skp1-Cul1-F-box ubiquitin ligase, which plays important roles in controlling numerous signaling pathways. Notably, β-TrCP induces ubiquitination and degradation of inhibitor of NF-κB (IκBα), thus triggering activation of NF-κB signaling. Here, we...

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Bibliographic Details
Main Authors: Jin Liu, Yukang Yuan, Jing Xu, Kui Xiao, Ying Xu, Tingting Guo, Liting Zhang, Jun Wang, Hui Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
ubiquitination
E3 ligase
β-TrCP
protein kinase D1
LPS
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02930/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02930/full

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