Prediction of compounds activity in nuclear receptor signaling and stress pathway assays using machine learning algorithms and low dimensional molecular descriptors
Toxicity evaluation of newly synthesized or used compounds is one of the main challenges during product development in many areas of industry. For example, toxicity is the second reason - after lack of efficacy - for failure in preclinical and clinical studies of drug candidates. To avoid attrition...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-12-01
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| Series: | Frontiers in Environmental Science |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fenvs.2015.00077/full |