IκB Kinase 2 Is Essential for IgE-Induced Mast Cell De Novo Cytokine Production but Not for Degranulation

IκB Kinase 2 Is Essential for IgE-Induced Mast Cell De Novo Cytokine Production but Not for Degranulation

The immunoglobulin E (IgE)-mediated mast cell (MC) response is central to the pathogenesis of type I allergy and asthma. IκB kinase 2 (IKK2) was reported to couple IgE-induced signals to MC degranulation by phosphorylating the SNARE protein SNAP23. We investigated MC responses in mice with MC-specif...

Full description

Bibliographic Details
Main Authors: Katrin Peschke, Anke Weitzmann, Klaus Heger, Rayk Behrendt, Nadja Schubert, Julia Scholten, David Voehringer, Karin Hartmann, Anne Dudeck, Marc Schmidt-Supprian, Axel Roers
Format: Article
Language:English
Published: Elsevier 2014-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714006305

Internet

http://www.sciencedirect.com/science/article/pii/S2211124714006305

Similar Items