Ameliorating Role of Caffeic Acid Phenethyl Ester (CAPE) Against Methotrexate-Induced Oxidative Stress in the Sciatic Nerve, Spinal Cord and Brain Stem Tissues of Rats

Ameliorating Role of Caffeic Acid Phenethyl Ester (CAPE) Against Methotrexate-Induced Oxidative Stress in the Sciatic Nerve, Spinal Cord and Brain Stem Tissues of Rats

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OBJECTIVE: Methotrexate (MTX)-associated neurotoxicity is an important clinical problem in cancer patients, but the mechanisms of MTX-induced neurotoxicity are not yet known exactly. The aims of this study were (1) to investigate the possible role of malondialdehyde (MDA), superoxide dismutase (SOD)...

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Bibliographic Details
Main Authors: Ertuğrul Uzar, Hasan Rıfat Koyuncuoğlu, H. Ramazan Yılmaz, Efkan Uz, Ahmet Songar, Onder Sahin, Vedat Ali Yurekli, Mustafa Yılmaz, Serkan Kılbaş, Süleyman Kutluhan
Format: Article
Language:English
Published: Galenos Yayinevi 2010-03-01
Series:Türk Nöroloji Dergisi
Subjects:
Caffeic acid phenethyl ester
methotrexate
oxidative stress
sciatic nerve
spinal cord
Online Access:http://www.tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-75436&look4=

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http://www.tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-75436&look4=

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