Eplerenone Attenuates Fibrosis in the Contralateral Kidney of UUO Rats by Preventing Macrophage-to-Myofibroblast Transition

Eplerenone Attenuates Fibrosis in the Contralateral Kidney of UUO Rats by Preventing Macrophage-to-Myofibroblast Transition

Severe renal fibrosis often occurs in obstructive kidney disease, not only in the obstructed kidney but also in the contralateral kidney, causing renal dysfunction. Although the mechanisms of injury in obstructed kidney have been studied for years, the pathogenesis of fibrosis in the contralateral k...

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Bibliographic Details
Main Authors: Yunzhao Xiong, Yi Chang, Juan Hao, Cuijuan Zhang, Fan Yang, Zheng Wang, Yunmeng Liu, Xiangting Wang, Shengyu Mu, Qingyou Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Pharmacology
Subjects:
UUO contralateral kidney
renal fibrosis
aldosterone
MR blockers
macrophage-to-myofibroblast-transition (MMT)
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.620433/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.620433/full

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