Analysis of human protein replacement stable cell lines established using snoMEN-PR vector.

The study of the function of many human proteins is often hampered by technical limitations, such as cytotoxicity and phenotypes that result from overexpression of the protein of interest together with the endogenous version. Here we present the snoMEN (snoRNA Modulator of gene ExpressioN) vector te...

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Bibliographic Details
Main Authors: Motoharu Ono, Kayo Yamada, Akinori Endo, Fabio Avolio, Angus I Lamond
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3636044?pdf=render