Nitrite elicits divergent NO-dependent signaling that associates with outcome in out of hospital cardiac arrest

Nitrite elicits divergent NO-dependent signaling that associates with outcome in out of hospital cardiac arrest

Brain and heart injury cause most out-of-hospital cardiac arrest deaths but limited pharmacotherapy exists to protect these tissues. Nitrite is a nitric oxide precursor that is protective in pre-clinical models of ischemic injury and safe in Phase I testing. Protection may occur by cGMP generation v...

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Bibliographic Details
Main Authors: Dario A. Vitturi, Charles Maynard, Michele Olsufka, Adam C. Straub, Nick Krehel, Peter J. Kudenchuk, Graham Nichol, Michael Sayre, Francis Kim, Cameron Dezfulian
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231719315046

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http://www.sciencedirect.com/science/article/pii/S2213231719315046

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