Structure-guided development of heterodimer-selective GPCR ligands

Structure-guided development of heterodimer-selective GPCR ligands

G protein-coupled receptors (GPCRs) are involved in key signalling pathways and represent important targets for the treatment of neurological and psychiatric disorders. Here, the authors describe powerful bivalent ligands that efficiently bind to therapeutically relevant GPCR heterodimers

Bibliographic Details
Main Authors: Harald Hübner, Tamara Schellhorn, Marie Gienger, Carolin Schaab, Jonas Kaindl, Laurin Leeb, Timothy Clark, Dorothee Möller, Peter Gmeiner
Format: Article
Language:English
Published: Nature Publishing Group 2016-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12298
id doaj-0157f3da6f7d40b3b16bfeb4284db320
record_format Article
spelling doaj-0157f3da6f7d40b3b16bfeb4284db3202021-05-11T11:03:06ZengNature Publishing GroupNature Communications2041-17232016-07-017111210.1038/ncomms12298Structure-guided development of heterodimer-selective GPCR ligandsHarald Hübner0Tamara Schellhorn1Marie Gienger2Carolin Schaab3Jonas Kaindl4Laurin Leeb5Timothy Clark6Dorothee Möller7Peter Gmeiner8Department of Chemistry and Pharmacy, Emil Fischer Center, Friedrich-Alexander-Universität Erlangen-NürnbergDepartment of Chemistry and Pharmacy, Emil Fischer Center, Friedrich-Alexander-Universität Erlangen-NürnbergDepartment of Chemistry and Pharmacy, Emil Fischer Center, Friedrich-Alexander-Universität Erlangen-NürnbergDepartment of Chemistry and Pharmacy, Emil Fischer Center, Friedrich-Alexander-Universität Erlangen-NürnbergDepartment of Chemistry and Pharmacy, Emil Fischer Center, Friedrich-Alexander-Universität Erlangen-NürnbergDepartment of Chemistry and Pharmacy, Emil Fischer Center, Friedrich-Alexander-Universität Erlangen-NürnbergDepartment of Chemistry and Pharmacy, Computer-Chemie-Center, Friedrich-Alexander-Universität Erlangen-NürnbergDepartment of Chemistry and Pharmacy, Emil Fischer Center, Friedrich-Alexander-Universität Erlangen-NürnbergDepartment of Chemistry and Pharmacy, Emil Fischer Center, Friedrich-Alexander-Universität Erlangen-NürnbergG protein-coupled receptors (GPCRs) are involved in key signalling pathways and represent important targets for the treatment of neurological and psychiatric disorders. Here, the authors describe powerful bivalent ligands that efficiently bind to therapeutically relevant GPCR heterodimershttps://doi.org/10.1038/ncomms12298
collection DOAJ
language English
format Article
sources DOAJ
author Harald Hübner
Tamara Schellhorn
Marie Gienger
Carolin Schaab
Jonas Kaindl
Laurin Leeb
Timothy Clark
Dorothee Möller
Peter Gmeiner
spellingShingle Harald Hübner
Tamara Schellhorn
Marie Gienger
Carolin Schaab
Jonas Kaindl
Laurin Leeb
Timothy Clark
Dorothee Möller
Peter Gmeiner
Structure-guided development of heterodimer-selective GPCR ligands
Nature Communications
author_facet Harald Hübner
Tamara Schellhorn
Marie Gienger
Carolin Schaab
Jonas Kaindl
Laurin Leeb
Timothy Clark
Dorothee Möller
Peter Gmeiner
author_sort Harald Hübner
title Structure-guided development of heterodimer-selective GPCR ligands
title_short Structure-guided development of heterodimer-selective GPCR ligands
title_full Structure-guided development of heterodimer-selective GPCR ligands
title_fullStr Structure-guided development of heterodimer-selective GPCR ligands
title_full_unstemmed Structure-guided development of heterodimer-selective GPCR ligands
title_sort structure-guided development of heterodimer-selective gpcr ligands
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-07-01
description G protein-coupled receptors (GPCRs) are involved in key signalling pathways and represent important targets for the treatment of neurological and psychiatric disorders. Here, the authors describe powerful bivalent ligands that efficiently bind to therapeutically relevant GPCR heterodimers
url https://doi.org/10.1038/ncomms12298
work_keys_str_mv AT haraldhubner structureguideddevelopmentofheterodimerselectivegpcrligands
AT tamaraschellhorn structureguideddevelopmentofheterodimerselectivegpcrligands
AT mariegienger structureguideddevelopmentofheterodimerselectivegpcrligands
AT carolinschaab structureguideddevelopmentofheterodimerselectivegpcrligands
AT jonaskaindl structureguideddevelopmentofheterodimerselectivegpcrligands
AT laurinleeb structureguideddevelopmentofheterodimerselectivegpcrligands
AT timothyclark structureguideddevelopmentofheterodimerselectivegpcrligands
AT dorotheemoller structureguideddevelopmentofheterodimerselectivegpcrligands
AT petergmeiner structureguideddevelopmentofheterodimerselectivegpcrligands
_version_ 1721447096511365120

Similar Items