Structure-guided development of heterodimer-selective GPCR ligands
G protein-coupled receptors (GPCRs) are involved in key signalling pathways and represent important targets for the treatment of neurological and psychiatric disorders. Here, the authors describe powerful bivalent ligands that efficiently bind to therapeutically relevant GPCR heterodimers
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2016-07-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12298 |