Tumor Genotyping and Homologous Recombination Repair Gene Variants in Patients With Epithelial Ovarian Cancer: Is Pathogenic Enough?

Tumor Genotyping and Homologous Recombination Repair Gene Variants in Patients With Epithelial Ovarian Cancer: Is Pathogenic Enough?

Our hypothesis was that the predictive accuracy of pathogenic variants in genes participating in the homologous recombination repair (HRR) system in patients with epithelial ovarian cancer (EOC) could be improved by considering additional next-generation sequencing (NGS) metrics. NGS genotyping was...

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Bibliographic Details
Main Authors: Elena Fountzilas, Vassiliki Kotoula, Georgia-Angeliki Koliou, Michalis Liontos, Kyriaki Papadopoulou, Eleni Giannoulatou, Alexios Papanikolaou, Ioannis Tikas, Sofia Chrisafi, Davide Mauri, Kyriakos Chatzopoulos, Florentia Fostira, Dimitrios Pectasides, Georgios Oikonomopoulos, Dimitra Aivazi, Angeliki Andrikopoulou, Anastasios Visvikis, Gerasimos Aravantinos, Flora Zagouri, George Fountzilas
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
biomarker
BRCA
co-mutation
homologous recombination repair
predictive
prognostic
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.683057/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.683057/full

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