Solid-Supported Proteins in the Liquid Chromatography Domain to Probe Ligand-Target Interactions

Solid-Supported Proteins in the Liquid Chromatography Domain to Probe Ligand-Target Interactions

Ligand-target interactions play a central role in drug discovery processes because these interactions are crucial in biological systems. Small molecules-proteins interactions can regulate and modulate protein function and activity through conformational changes. Therefore, bioanalytical tools to scr...

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Bibliographic Details
Main Authors: Marcela Cristina de Moraes, Carmen Lucia Cardoso, Quezia Bezerra Cass
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Chemistry
Subjects:
bioaffinity chromatography
ligand screening
ligand-target interactions
zonal bioaffinity chromatography
frontal bioaffinity chromatography
ligand fishing
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00752/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2019.00752/full

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