The transition state and regulation of γ-TuRC-mediated microtubule nucleation revealed by single molecule microscopy

The transition state and regulation of γ-TuRC-mediated microtubule nucleation revealed by single molecule microscopy

Determining how microtubules (MTs) are nucleated is essential for understanding how the cytoskeleton assembles. While the MT nucleator, γ-tubulin ring complex (γ-TuRC) has been identified, precisely how γ-TuRC nucleates a MT remains poorly understood. Here, we developed a single molecule assay to di...

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Bibliographic Details
Main Authors: Akanksha Thawani, Michael J Rale, Nicolas Coudray, Gira Bhabha, Howard A Stone, Joshua W Shaevitz, Sabine Petry
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-06-01
Series:eLife
Subjects:
microtubule nucleation
gamma-tubulin
gamma-tubulin ring complex
microtubule
transition state
XMAP215
Online Access:https://elifesciences.org/articles/54253

Internet

https://elifesciences.org/articles/54253

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