Dynamic nuclear envelope phenotype in rats overexpressing mutated human torsinA protein

Dynamic nuclear envelope phenotype in rats overexpressing mutated human torsinA protein

A three-base-pair deletion in the human TOR1A gene is causative for the most common form of primary dystonia: the early-onset dystonia type 1 (DYT1 dystonia). The pathophysiological consequences of this mutation are still unknown. To study the pathology of the mutant torsinA (TOR1A) protein, we have...

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Bibliographic Details
Main Authors: Libo Yu-Taeger, Viktoria Gaiser, Larissa Lotzer, Tina Roenisch, Benedikt Timo Fabry, Janice Stricker-Shaver, Nicolas Casadei, Michael Walter, Martin Schaller, Olaf Riess, Huu Phuc Nguyen, Thomas Ott, Kathrin Grundmann-Hauser
Format: Article
Language:English
Published: The Company of Biologists 2018-07-01
Series:Biology Open
Subjects:
DYT1 dystonia
TorsinA
Transgenic
Rat
Nuclear envelope
Pathology
Online Access:http://bio.biologists.org/content/7/7/bio032839

Internet

http://bio.biologists.org/content/7/7/bio032839

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