p53 Is Abnormally Elevated and Active in the CNS of Patients with Amyotrophic Lateral Sclerosis

p53 Is Abnormally Elevated and Active in the CNS of Patients with Amyotrophic Lateral Sclerosis

Motor neuron degeneration in amyotrophic lateral sclerosis (ALS) is a form of apoptosis, but the mechanisms for this neuronal cell death are not known. We evaluated whether motor neuron degeneration in ALS is associated with changes in the levels and function of the apoptosis regulating protein p53....

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Bibliographic Details
Main Author: Lee J. Martin
Format: Article
Language:English
Published: Elsevier 2000-12-01
Series:Neurobiology of Disease
Subjects:
motor neuron
apoptosis
DNA damage
oxidative stress
programmed cell death
Lou Gehrig's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996100903140

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http://www.sciencedirect.com/science/article/pii/S0969996100903140

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