Overview: Systemic Inflammatory Response Derived From Lung Injury Caused by SARS-CoV-2 Infection Explains Severe Outcomes in COVID-19

Overview: Systemic Inflammatory Response Derived From Lung Injury Caused by SARS-CoV-2 Infection Explains Severe Outcomes in COVID-19

Most SARS-CoV2 infections will not develop into severe COVID-19. However, in some patients, lung infection leads to the activation of alveolar macrophages and lung epithelial cells that will release proinflammatory cytokines. IL-6, TNF, and IL-1β increase expression of cell adhesion molecules (CAMs)...

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Bibliographic Details
Main Authors: Rafael B. Polidoro, Robert S. Hagan, Roberta de Santis Santiago, Nathan W. Schmidt
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV2
COVID-19
severe COVID-19
bisphosphonates
inflammatory monocytes
ARDS
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01626/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01626/full

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