Diabetes Attenuates the Contribution of Endogenous Nitric Oxide but Not Nitroxyl to Endothelium Dependent Relaxation of Rat Carotid Arteries

Diabetes Attenuates the Contribution of Endogenous Nitric Oxide but Not Nitroxyl to Endothelium Dependent Relaxation of Rat Carotid Arteries

Introduction:Endothelial dysfunction is a major risk factor for several of the vascular complications of diabetes, including ischemic stroke. Nitroxyl (HNO), the one electron reduced and protonated form of nitric oxide (NO•), is resistant to scavenging by superoxide, but the role of HNO in diabetes...

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Bibliographic Details
Main Authors: Jasmin Chendi Li, Anida Velagic, Cheng Xue Qin, Mandy Li, Chen Huei Leo, Barbara K. Kemp-Harper, Rebecca H. Ritchie, Owen L. Woodman
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
nitric oxide
nitroxyl
Diabetes
endothelium
carotid arteries, nitroxyl mediated relaxation in diabetes
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.585740/full

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https://www.frontiersin.org/articles/10.3389/fphar.2020.585740/full

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