Dysregulation of suppressor of cytokine signaling 3 in keratinocytes causes skin inflammation mediated by interleukin-20 receptor-related cytokines.

Dysregulation of suppressor of cytokine signaling 3 in keratinocytes causes skin inflammation mediated by interleukin-20 receptor-related cytokines.

Homeostatic regulation of epidermal keratinocytes is controlled by the local cytokine milieu. However, a role for suppressor of cytokine signaling (SOCS), a negative feedback regulator of cytokine networks, in skin homeostasis remains unclear. Keratinocyte specific deletion of Socs3 (Socs3 cKO) caus...

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Bibliographic Details
Main Authors: Ayako Uto-Konomi, Kosuke Miyauchi, Naoko Ozaki, Yasutaka Motomura, Yoshie Suzuki, Akihiko Yoshimura, Shinobu Suzuki, Daniel Cua, Masato Kubo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3390387?pdf=render

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http://europepmc.org/articles/PMC3390387?pdf=render

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