GLI1 Inhibitor SRI-38832 Attenuates Chemotherapeutic Resistance by Downregulating NBS1 Transcription in BRAFV600E Colorectal Cancer

GLI1 Inhibitor SRI-38832 Attenuates Chemotherapeutic Resistance by Downregulating NBS1 Transcription in BRAFV600E Colorectal Cancer

Resistance to radiation and chemotherapy in colorectal cancer (CRC) patients contribute significantly to refractory disease and disease progression. Herein, we provide mechanistic rationale for acquired or inherent chemotherapeutic resistance to the anti-tumor effects of 5-fluorouracil (5-FU) that i...

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Bibliographic Details
Main Authors: Ruowen Zhang, Jinlu Ma, Justin T. Avery, Vijaya Sambandam, Theresa H. Nguyen, Bo Xu, Mark J. Suto, Rebecca J. Boohaker
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
5-FU resistance
DNA damage repair
GLI1 target gene
novel GLI1 inhibitor
target therapy
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00241/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00241/full

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