mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion

Abstract Intestinal ischemia reperfusion (I/R) injury is the important pathogenesis for acute intestinal barrier disruption. The STING signaling is associated with gut homeostasis and barrier integrity. However, the biological function and regulation of STING signaling in intestinal I/R injury are n...

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Bibliographic Details
Main Authors: Xufei Zhang, Jie Wu, Qinjie Liu, Xuanheng Li, Sicheng Li, Jun Chen, Zhiwu Hong, Xiuwen Wu, Yun Zhao, Jianan Ren
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-020-03239-6