CD38 in Adenosinergic Pathways and Metabolic Re-programming in Human Multiple Myeloma Cells: In-tandem Insights From Basic Science to Therapy

CD38 in Adenosinergic Pathways and Metabolic Re-programming in Human Multiple Myeloma Cells: In-tandem Insights From Basic Science to Therapy

Tumor microenvironments are rich in extracellular nucleotides that can be metabolized by ectoenzymes to produce adenosine, a nucleoside involved in controlling immune responses. Multiple myeloma, a plasma cell malignancy developed within a bone marrow niche, exploits adenosinergic pathways to custom...

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Bibliographic Details
Main Authors: Alberto L. Horenstein, Cristiano Bracci, Fabio Morandi, Fabio Malavasi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
CD38
multiple myeloma
metabolic reprogramming
adenosine
immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00760/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00760/full

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