Downregulation of Soluble Guanylate Cyclase and Protein Kinase G With Upregulated ROCK2 in the Pulmonary Artery Leads to Thromboxane A2 Sensitization in Monocrotaline-Induced Pulmonary Hypertensive Rats

Downregulation of Soluble Guanylate Cyclase and Protein Kinase G With Upregulated ROCK2 in the Pulmonary Artery Leads to Thromboxane A2 Sensitization in Monocrotaline-Induced Pulmonary Hypertensive Rats

Thromboxane A2 (TXA2) promotes various physiological responses including pulmonary artery (PA) contraction, and pathophysiological implications have been suggested in cardiovascular diseases including pulmonary hypertension. Here, we investigated the role of TXA2 receptor (TP)-mediated signaling in...

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Bibliographic Details
Main Authors: Suhan Cho, Hyun Namgoong, Hae Jin Kim, Rany Vorn, Hae Young Yoo, Sung Joon Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Physiology
Subjects:
pulmonary hypertension
pulmonary artery smooth muscle
guanylate cyclase
protein kinase G
thromboxane A2 (TXA2)
monocrotaline
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.624967/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.624967/full

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