Broad-Spectrum Antimicrobial Activity and Improved Stability of a D-Amino Acid Enantiomer of DMPC-10A, the Designed Derivative of Dermaseptin Truncates

Broad-Spectrum Antimicrobial Activity and Improved Stability of a D-Amino Acid Enantiomer of DMPC-10A, the Designed Derivative of Dermaseptin Truncates

DMPC-10A (ALWKKLLKK-Cha-NH<sub>2</sub>) is a 10-mer peptide derivative from the N-terminal domain of Dermaseptin-PC which has shown broad-spectrum antimicrobial activity as well as a considerable hemolytic effect. In order to reduce hemolytic activity and improve stability to endogenous...

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Bibliographic Details
Main Authors: Yu Zai, Yuan Ying, Zhuming Ye, Mei Zhou, Chengbang Ma, Zhanzhong Shi, Xiaoling Chen, Xinping Xi, Tianbao Chen, Lei Wang
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Antibiotics
Subjects:
antimicrobial peptide
D-amino acid
protease stability
<i>Galleria mellonella </i>larva model
Online Access:https://www.mdpi.com/2079-6382/9/9/627

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https://www.mdpi.com/2079-6382/9/9/627

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