Mechanochemical Synthesis and Structure of the Tetrahydrate and Mesoporous Anhydrous Metforminium(2+)-<i>N</i>,<i>N</i>′-1,4-Phenylenedioxalamic Acid (1:2) Salt: The Role of Hydrogen Bonding and n→π * Charge Assisted Interactions

Mechanochemical Synthesis and Structure of the Tetrahydrate and Mesoporous Anhydrous Metforminium(2+)-<i>N</i>,<i>N</i>′-1,4-Phenylenedioxalamic Acid (1:2) Salt: The Role of Hydrogen Bonding and n→π * Charge Assisted Interactions

A new organic salt of metformin, an antidiabetic drug, and <i>N</i>,<i>N</i>′-(1,4-phenylene)dioxalamic acid, was mechanochemically synthesized, purified by crystallization from solution and characterized by single X-ray crystallography. The structure revealed a salt-type cry...

Full description

Bibliographic Details
Main Authors: Sayuri Chong-Canto, Efrén V. García-Báez, Francisco J. Martínez-Martínez, Angel A. Ramos-Organillo, Itzia I. Padilla-Martínez
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Pharmaceutics
Subjects:
metformin cocrystal
mechanochemical synthesis
dicationic metformin
water channels
pi-interactions
mesoporous anhydrate
Online Access:https://www.mdpi.com/1999-4923/12/10/998

Internet

https://www.mdpi.com/1999-4923/12/10/998

Similar Items