Epigenetically-inherited centromere and neocentromere DNA replicates earliest in S-phase.

Eukaryotic centromeres are maintained at specific chromosomal sites over many generations. In the budding yeast Saccharomyces cerevisiae, centromeres are genetic elements defined by a DNA sequence that is both necessary and sufficient for function; whereas, in most other eukaryotes, centromeres are...

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Bibliographic Details
Main Authors: Amnon Koren, Hung-Ji Tsai, Itay Tirosh, Laura S Burrack, Naama Barkai, Judith Berman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-08-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2924309?pdf=render