The Effects of Antipsychotics on the Synaptic Plasticity Gene <i>Homer1a</i> Depend on a Combination of Their Receptor Profile, Dose, Duration of Treatment, and Brain Regions Targeted

The Effects of Antipsychotics on the Synaptic Plasticity Gene <i>Homer1a</i> Depend on a Combination of Their Receptor Profile, Dose, Duration of Treatment, and Brain Regions Targeted

Background: Antipsychotic agents modulate key molecules of the postsynaptic density (PSD), including the <i>Homer1a</i> gene, implicated in dendritic spine architecture. How the antipsychotic receptor profile, dose, and duration of administration may influence synaptic plasticity and the...

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Bibliographic Details
Main Authors: Felice Iasevoli, Elisabetta Filomena Buonaguro, Camilla Avagliano, Annarita Barone, Anna Eramo, Licia Vellucci, Andrea de Bartolomeis
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
psychosis
synaptic plasticity
gene expression
dopamine
glutamate
haloperidol
Online Access:https://www.mdpi.com/1422-0067/21/15/5555

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https://www.mdpi.com/1422-0067/21/15/5555

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