MF59- and Al(OH)3-adjuvanted Staphylococcus aureus (4C-Staph) vaccines induce sustained protective humoral and cellular immune responses, with a critical role for effector CD4 T cells at low antibody titers.

MF59- and Al(OH)3-adjuvanted Staphylococcus aureus (4C-Staph) vaccines induce sustained protective humoral and cellular immune responses, with a critical role for effector CD4 T cells at low antibody titers.

Staphylococcus aureus (S. aureus) is an important opportunistic pathogen that may cause invasive life-threatening infections like sepsis and pneumonia. Due to increasing antibiotic-resistance, the development of an effective vaccine against S. aureus is needed. Although a correlate of protection aga...

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Bibliographic Details
Main Authors: Elisabetta eMonaci, Francesca eMancini, Giuseppe eLofano, Marta eBacconi, Simona eTavarini, Chiara eSammicheli, Letizia eArcidiacono, Monica eGiraldi, Bruno eGaletti, Silvia eRossi Paccani, Antonina eTorre, Maria Rita eFontana, Guido eGrandi, Ennio eDe Gregorio, Giuliano eBensi, Emiliano eChiarot, Sandra eNuti, Fabio eBagnoli, Elisabetta eSoldaini, Sylvie eBertholet
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Immunology
Subjects:
Antibodies
Mice
Staphylococcus aureus
Vaccination
T cells
Bacterial infection
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00439/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00439/full

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