Characterization and applications of a Crimean-Congo hemorrhagic fever virus nucleoprotein-specific Affimer: Inhibitory effects in viral replication and development of colorimetric diagnostic tests.

Characterization and applications of a Crimean-Congo hemorrhagic fever virus nucleoprotein-specific Affimer: Inhibitory effects in viral replication and development of colorimetric diagnostic tests.

Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV) is one of the most widespread medically important arboviruses, causing human infections that result in mortality rates of up to 60%. We describe the selection of a high-affinity small protein (Affimer-NP) that binds specifically to the nucleopr...

Full description

Bibliographic Details
Main Authors: Beatriz Álvarez-Rodríguez, Christian Tiede, Alexis C R Hoste, Rebecca A Surtees, Chi H Trinh, Gillian S Slack, John Chamberlain, Roger Hewson, Alba Fresco, Patricia Sastre, Darren C Tomlinson, Paul A Millner, Thomas A Edwards, John N Barr
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-06-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0008364

Internet

https://doi.org/10.1371/journal.pntd.0008364

Similar Items