Expression of selected pathway-marker genes in human urothelial cells exposed chronically to a non-cytotoxic concentration of monomethylarsonous acid

Expression of selected pathway-marker genes in human urothelial cells exposed chronically to a non-cytotoxic concentration of monomethylarsonous acid

Bladder cancer has been associated with chronic arsenic exposure. Monomethylarsonous acid [MMA(III)] is a metabolite of inorganic arsenic and has been shown to transform an immortalized urothelial cell line (UROtsa) at concentrations 20-fold less than arsenite. MMA(III) was used as a model arsenical...

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Bibliographic Details
Main Authors: Matthew Medeiros, Tam Minh Le, Daniel Troup, Petr Novak, A. Jay Gandolfi
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Toxicology Reports
Subjects:
Arsenic
Arsenical
Urinary bladder
Carcinogenesis
Gene expression
Urothelial cells
PCR array
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750014000481

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http://www.sciencedirect.com/science/article/pii/S2214750014000481

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