Accurate imputation of human leukocyte antigens with CookHLA

Accurate imputation of human leukocyte antigens with CookHLA

Human leukocyte antigen (HLA) genes influence many immune phenotypes, however methods to impute HLA type have been limited in accuracy. Here, the authors present an HLA imputation method, CookHLA, which uses locally embedded prediction markers to adaptively impute HLA genes across a range of scenari...

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Bibliographic Details
Main Authors: Seungho Cook, Wanson Choi, Hyunjoon Lim, Yang Luo, Kunhee Kim, Xiaoming Jia, Soumya Raychaudhuri, Buhm Han
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21541-5
Description
Summary:Human leukocyte antigen (HLA) genes influence many immune phenotypes, however methods to impute HLA type have been limited in accuracy. Here, the authors present an HLA imputation method, CookHLA, which uses locally embedded prediction markers to adaptively impute HLA genes across a range of scenarios.
ISSN:2041-1723

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