A novel role for activating transcription factor-2 in 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis*

A novel role for activating transcription factor-2 in 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis*

To investigate the mechanisms underlying 15(S)-HETE-induced angiogenesis, we have studied the role of the small GTPase, Rac1. We find that 15(S)-HETE activated Rac1 in human retinal microvascular endothelial cells (HRMVEC) in a time-dependent manner. Blockade of Rac1 by adenovirus-mediated expressio...

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Bibliographic Details
Main Authors: Tieqiang Zhao, Dong Wang, Sergey Y. Cheranov, Manjula Karpurapu, Koteswara R. Chava, Venkatesh Kundumani-Sridharan, Dianna A. Johnson, John S. Penn, Gadiparthi N. Rao
Format: Article
Language:English
Published: Elsevier 2009-03-01
Series:Journal of Lipid Research
Subjects:
eicosanoid
Rac1
retinal neovascularization
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520308956

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http://www.sciencedirect.com/science/article/pii/S0022227520308956

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