2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia

2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia

The metabolic response to endotoxemia closely mimics those seen in sepsis. Here, we show that the urinary excretion of the metabolite 2-hydroxyglutarate (2HG) is dramatically suppressed following lipopolysaccharide (LPS) administration in vivo, and in human septic patients. We further show that enha...

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Bibliographic Details
Main Authors: Susan F. Fitzpatrick, Simon Lambden, David Macias, Zudin Puthucheary, Sandra Pietsch, Lee Mendil, Mark J. W. McPhail, Randall S. Johnson
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Physiology
Subjects:
2-hydroxyglutarate
endotoxemia
sepsis
hypothermia
2-hydroxygluterate dehydrogenase
iNOS
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00147/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00147/full

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