Comparative cardiac toxicity of anthracyclines in vitro and in vivo in the mouse.

Comparative cardiac toxicity of anthracyclines in vitro and in vivo in the mouse.

The antineoplastic efficacy of anthracyclines is limited by their cardiac toxicity. In this study, we evaluated the toxicity of doxorubicin, non-pegylated liposomal-delivered doxorubicin, and epirubicin in HL-1 adult cardiomyocytes in culture as well as in the mouse in vivo.The cardiomyocytes were i...

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Bibliographic Details
Main Authors: Stefano Toldo, Rachel W Goehe, Marzia Lotrionte, Eleonora Mezzaroma, Evan T Sumner, Giuseppe G L Biondi-Zoccai, Ignacio M Seropian, Benjamin W Van Tassell, Francesco Loperfido, Giovanni Palazzoni, Norbert F Voelkel, Antonio Abbate, David A Gewirtz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3597611?pdf=render

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http://europepmc.org/articles/PMC3597611?pdf=render

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