Direct detection of ABCA1-dependent HDL formation based on lipidation-induced hydrophobicity change in apoA-I[S]

Direct detection of ABCA1-dependent HDL formation based on lipidation-induced hydrophobicity change in apoA-I[S]

ABCA1 mediates the efflux of cholesterol and phospholipids into apoA-I to form HDL, which is important in the prevention of atherosclerosis. To develop a novel method for the evaluation of HDL formation, we prepared an apoA-I-POLARIC by labeling the specific residue of an apoA-I variant with a hydro...

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Bibliographic Details
Main Authors: Risa Omura, Kohjiro Nagao, Norihiro Kobayashi, Kazumitsu Ueda, Hiroyuki Saito
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Journal of Lipid Research
Subjects:
cholesterol efflux
POLARIC
hydrophobicity-sensitive fluorescence probe
ATP binding cassette transporter A1
high density lipoprotein
apolipoprotein A-I
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520349944

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http://www.sciencedirect.com/science/article/pii/S0022227520349944

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